Clinically important drug interactions with opioid and non-opioid analgesics
نویسندگان
چکیده
منابع مشابه
Non-opioid analgesics
C describe the concept of multimodal analgesia and give examples Abstract Opium is the natural substance to which modern narcotics owe their existence. First discovered in the 1500s, opium was the most potent analgesic compound in use, held in high regard, hence its Latin name laudanum (to praise). Subsequent studies into the effects of opium led to the discovery of the opioid receptors, and th...
متن کاملSynergistic interactions between cannabinoid and opioid analgesics.
Cannabinoids and opioids both produce analgesia through a G-protein-coupled mechanism that blocks the release of pain-propagating neurotransmitters in the brain and spinal cord. However, high doses of these drugs, which may be required to treat chronic, severe pain, are accompanied by undesirable side effects. Thus, a search for a better analgesic strategy led to the discovery that delta 9-tetr...
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BACKGROUND Opioids are the most frequently used drugs to treat pain in cancer patients. In some patients, however, opioids can cause adverse effects and drug-drug interactions. No advice concerning the combination of opioids and other drugs is given in the current European guidelines. OBJECTIVE To identify studies that report clinically significant drug-drug interactions involving opioids use...
متن کاملOpioid Analgesics
Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...
متن کاملNON OPIOID ANALGESICS and ANTI-INFLAMMATORY MEDICATIONS
Paracetamol has analgesic and antipyretic e ects that are similar to aspirin, but little or no antiin ammatory activity. It is generally accepted that it has little e ect on extracerebral COX-1 or COX-2, although it inhibits central COX-3. Consequently, it prevents the enhanced synthesis of prostaglandin E2 in the hypothalamus during pyrexia, and thus reduces elevated body temperature. It has s...
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ژورنال
عنوان ژورنال: Arhiv za farmaciju
سال: 2018
ISSN: 0004-1963,2217-8767
DOI: 10.5937/arhfarm1806071v